Type 1 diabetes affects approximately one million Americans, and is usually diagnosed in children and young adults. Type 1 diabetes arises from the autoimmune destruction of islet cells in the pancreas. Due to the body's inability to produce insulin, insulin must be replaced, primarily through daily injections, in order to control plasma glucose.

While insulin replacement provides a life-sustaining therapy, it is not a cure, and many individuals develop significant disease-associated complications, including those of the eye, kidney, and heart. While progress has been made in the ability to identify individuals likely to develop the disorder, scientific understanding of the disease has been limited by practical considerations in studying humans with the condition.

Much of the understanding of the disease is derived from rodent models, particularly the non-obese diabetic (NOD) mouse. Although numerous therapies have been shown to inhibit the development of type 1 diabetes in this model, the success in advancing therapies to human patients has been limited.

In collaboration with the American Diabetes Association, Entelos developed the Type 1 Diabetes PhysioLab platform to address key scientific questions related to the disease's onset and progression in the NOD mouse. This platform is currently being used to develop a better understanding of the human disease, and research within it has already yielded insights into how discrepancies in dosing, duration, and timing could potentially account for the failure of many clinically tested type 1 diabetes therapies.

To learn more download:

• Diabetes Research Center (DRC) Education Package:
  Application of In Silico Modeling and Biosimulation to Type 1 Diabetes Research
• Overview of ADA/Entelos Type 1 Diabetes Collaboration
• Human and Economic Toll of Diabetes and the American Diabetes Association's Role

Press releases:

• American Diabetes Association and Entelos Announce In Silico Research Funding Opportunity
  January 17, 2007
• American Diabetes Association Announces Launch of In Silico Diabetes Research Center
  June 11, 2006
• Entelos Publication in Immunity Reveals Potential Reasons for Type 1 Diabetes Drug Failures
  24 August, 2005
• Entelos Presents Type 1 Diabetes Model and Scientific Insights at the 65th Annual American Diabetes Association Meeting
  12 June, 2005
• Entelos Presents Comparative Analysis Results in an Oral Session at the 65th Annual American Diabetes Association Meeting
  11 June, 2005
• American Diabetes Association and Entelos Develop Computer Model for Type 1 Diabetes
  3 May, 2005
• Entelos Builds First In Silico Animal Model for Type 1 Diabetes
  8 June, 2004
• ADA Initiates Cutting-Edge Research Program to Prevent Type 1 Diabetes
  5 June, 2004

• Overview

• ADA Collaboration

• Organon Collaboration

• J&JPRD Collaboration